EXTRACELLULAR VESICLES FROM HAIR FOLLICLE-DERIVED MESENCHYMAL STROMAL CELLS: ISOLATION, CHARACTERIZATION AND THERAPEUTIC POTENTIAL FOR CHRONIC WOUND HEALING

Abstract Background Mesenchymal stromal cells (MSCs) and their extracellular vesicles (MSC-EVs) have demonstrated to elicit immunomodulatory and pro-regenerative properties that are beneficial for the treatment of chronic wounds.Thanks to different mediators, MSC-EVs have shown to play an important role in the proliferation, migration and cell surv

The deformability of a red blood cell (RBC) is one of the most important biological parameters affecting blood flow, both in large arteries and in the microcirculation, and hence it can be used to quantify the cell state.Despite numerous studies on the mechanical properties of RBCs, including cell rigidity, much is still unknown about the relations

Abstract Endometriosis (EMS) is a prevalent gynecological condition lacking reliable diagnostic biomarkers.This prospective study aimed to analyze the potential of serum heat shock transcription factor 1 (HSF1) as a diagnostic marker for EMS.Clinical features of 92 EMS Futurama patients and 52 controls were recorded, revealing significant differenc

A 74-year-old transgender female presented with urinary difficulty and a painful lesion at her neo-vagina, 47 years after undergoing gender-affirming vaginoplasty.Initial biopsy reported Low-Grade Squamous Intraepithelial Lesion Heating Pads (LGSIL), while MRI revealed no inguinal or pelvic lymphadenopathy.Patient underwent partial neo-vaginectomy

In a gradually more interlinked world, the formation of collaborations with partners is increasingly regarded as an important driver for generating innovation.Although multidimensional proximities are important factors influencing interorganizational coinnovation performance, relevant empirical studies have not reached consistent conclusions.By foc